Hemostatic therapy should be used for acute treatment of anticoagulation-related intracerebral hemorrhage.

نویسندگان

  • Michael N Diringer
  • Allyson R Zazulia
چکیده

The Questions: (1) Should the patient receive vitamin K and fresh-frozen plasma on evaluation in the emergency department to reverse international normalized ratio? (2) If so, what is the appropriate targeted international normalized ratio level? (3) Should other hemostatic agents such as prothrombin complex concentrates or NovoSeven be used instead of (or in combination with) fresh-frozen plasma?

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hemostatic therapy should not be used for acute treatment of anticoagulation-related intracerebral hemorrhage.

“Just say no” was the slogan used in a US advertising campaign in the mid-1980s discouraging young people from engaging in recreational and potentially harmful drug use. In the context of this controversy, the same motto comes to mind when considering the routine use of conceptually exciting but medically unproven therapies outside the setting of controlled clinical studies. Trial-and-error tre...

متن کامل

Management of Spontaneous Intracerebral Hemorrhage

PURPOSE OF REVIEW We review the current evidence for medical and surgical treatments of spontaneous intracerebral hemorrhage (ICH). RECENT FINDINGS Therapy with hemostatic agents (e.g. factor VIIa and tranexamic acid) if started early after bleeding onset may reduce hematoma expansion, but their clinical effectiveness has not been shown. Rapid anticoagulation reversal with prothrombin concent...

متن کامل

Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion.

Wider use of oral anticoagulants has led to an increasing frequency of warfarin-related intracerebral hemorrhage (ICH). The high early mortality of approximately 50% has remained stable in recent decades. In contrast to spontaneous ICH, the duration of bleeding is 12 to 24 hours in many patients, offering a longer opportunity for intervention. Treatment varies widely, and optimal therapy has ye...

متن کامل

Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis.

BACKGROUND AND PURPOSE Warfarin increases both the likelihood and the mortality of intracerebral hemorrhage (ICH), particularly in patients with a history of prior ICH. In light of this consideration, should a patient with both a history of ICH and a clear indication for anticoagulation such as nonvalvular atrial fibrillation be anticoagulated? In the absence of data from a clinical trial, we u...

متن کامل

Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies.

Little is known about the pathophysiology of intracerebral haemorrhage that occurs during anticoagulant treatment. In observational studies, investigators have reported larger haematoma volumes and worse functional outcome in these patients than in those with intracerebral haemorrhage and a normal coagulation status. The need to prevent extensive haematoma enlargement by rapid reversal of the a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Stroke

دوره 43 9  شماره 

صفحات  -

تاریخ انتشار 2012